Research Interests
Microphysiological Systems, Stem cell, Vasculature, Organoids, Mechanobiology, Cancer biology, CAR, Immunotherapy, Immunology, Infectious disease, Synthetic Biology, Aging
01
Perfusable Vascularized Organoid-on-a-chip model
The Organoid platform has shown great potential for drug development, but it lacks a crucial component - perfusable vasculature. Without blood vessels, organoids can form a necrotic core, making them unsuitable for long-term culture to study aging-related diseases. To address this issue, there is a growing interest in engineering more complex vascularized organoid-on-a-chip models, particularly for brain and liver organoids. Such models can provide chemical gradients and biophysical stimuli, making them invaluable tools for research.
02
Vascularized Tumor-on-a-chip
Solid tumors are known to be highly vascularized, with vasculatures surrounding and inside the tumor region. However, in vitro tumor models face a technical challenge as blood vessels are unable to grow inside the tumor. To address this issue, there is a need to develop a fully vascularized tumor-on-a-chip model, where blood vessels can penetrate inside the tumor region. Such models can be used for immunotherapy evaluation and hold great promise for future research.
03
Immunoengineering
Tertiary lymphoid structures (TLS) have become a topic of great interest due to their potential prognostic and predictive value in cancer and autoimmune diseases. An in vitro model that mimics this vascularized immune tissue can provide valuable insights into the functions of TLS. Such a model can be a powerful tool for researchers seeking to better understand the role of TLS in these diseases.
04
Microvasculature-on-a-chip
The circulation system is an essential part of our body, responsible for transporting nutrients, oxygen, and cells through blood vessels. However, many aspects of vasculogenesis and angiogenesis remain unclear, and blood vessels play a crucial role in various physiological and pathological events, including metastasis. A microvasculature-on-a-chip model can provide a robust platform for studying these phenomena in detail.
